Molecular Neuroscience
本课程在分子水平上探讨神经系统的结构与功能，内容包括神经元特异性基因表达调控、离子通道与受体的分子结构、突触传递的分子机制、神经发育的分子基础、学习记忆的分子机制、以及神经退行性疾病的分子机制。课程介绍基因敲除、光遗传学、单分子成像等前沿技术，培养学生的分子生物学思维。
This course explores nervous system structure and function at the molecular level. Topics include neuron-specific gene expression regulation, molecular structure of ion channels and receptors, molecular mechanisms of synaptic transmission, molecular basis of neural development, molecular mechanisms of learning and memory, and molecular mechanisms of neurodegenerative diseases. Covers cutting-edge techniques like knockout, optogenetics, and single-molecule imaging.
学生需从GEO数据库下载阿尔茨海默病患者和对照的脑组织基因表达数据，使用R或Python进行差异表达分析，筛选与疾病相关的关键基因，构建蛋白相互作用网络和信号通路图，分析关键基因的生物学功能，撰写完整的生物信息学分析报告，培养学生的组学数据分析能力。
Students download brain tissue gene expression data of Alzheimer's patients and controls from the GEO database, perform differential expression analysis using R or Python, screen key disease-related genes, construct protein interaction networks and signaling pathway maps, analyze biological functions of key genes, and write a complete bioinformatics analysis report.