Neurophysiology
本课程深入探讨神经系统的电生理特性和信号传导机制。内容包括神经元膜的生物物理特性、离子通道的结构与功能、动作电位的产生与传导、突触传递的分子机制、神经递质释放与受体作用、神经元整合特性、以及神经网络的活动规律。课程配有电生理实验，学习膜片钳等技术的基本原理。
This course explores the electrophysiological properties and signal transduction mechanisms of the nervous system. Content covers the biophysical properties of neuronal membranes, ion channel structure and function, action potential generation and conduction, molecular mechanisms of synaptic transmission, neurotransmitter release and receptor action, neuronal integration properties, and neural network activity patterns. Includes electrophysiology lab with patch-clamp technique fundamentals.
学生需使用NEURON软件或Python编写Hodgkin-Huxley模型，模拟神经元动作电位的产生过程。通过调整钠通道、钾通道电导等参数，观察动作电位波形、阈值、不应期等特性的变化，分析离子通道动力学对神经元兴奋性的影响，并撰写实验报告，培养学生的计算建模和数据分析能力。
Students use NEURON software or Python to implement the Hodgkin-Huxley model and simulate action potential generation. By adjusting sodium and potassium channel conductances, they observe changes in waveform, threshold, and refractory period, analyzing how ion channel dynamics affect neuronal excitability. Develops computational modeling and data analysis skills.