Metabolic Biochemistry
本课程系统讲授生物体内物质代谢和能量转换的基本规律。内容涵盖糖代谢（糖酵解、三羧酸循环、磷酸戊糖途径、糖异生、糖原代谢）、脂代谢（脂肪酸氧化、酮体生成、脂类合成）、氨基酸代谢（脱氨基、转氨基、尿素循环）、核苷酸代谢及代谢调控网络。重点理解各代谢途径的关键酶、调控机制及途径间的相互联系，掌握代谢紊乱与疾病的关系，为后续专业学习和研究奠定理论基础。
This course systematically covers the fundamental principles of substance metabolism and energy conversion in living organisms. Topics include carbohydrate metabolism (glycolysis, TCA cycle, pentose phosphate pathway, gluconeogenesis, glycogen metabolism), lipid metabolism (fatty acid oxidation, ketogenesis, lipid synthesis), amino acid metabolism (deamination, transamination, urea cycle), nucleotide metabolism, and metabolic regulatory networks. Emphasis on key enzymes, regulatory mechanisms, and pathway interconnections.
学生需以II型糖尿病为研究对象，系统分析糖代谢和脂代谢各主要通路在病理状态下的变化。内容包括绘制糖酵解、糖异生、脂肪酸合成与氧化等关键通路的示意图，标注关键酶的表达活性变化，分析胰岛素信号通路对代谢的调控作用，探讨代谢紊乱间的因果关系。报告需结合文献综述通路变化机制并提出潜在的药物干预靶点。
Students systematically analyze changes in glucose and lipid metabolism pathways in type II diabetes. The project includes mapping key pathways such as glycolysis, gluconeogenesis, fatty acid synthesis and oxidation, labeling expression and activity changes of key enzymes, analyzing insulin signaling pathway regulation of metabolism, and exploring causal relationships among metabolic disturbances. The report reviews mechanisms of pathway changes and proposes potential drug intervention targets based on literature.