Developmental Neuroscience
本课程研究神经系统从胚胎到成熟的发育过程，内容包括神经板形成与神经管闭合、神经诱导与模式建成、神经元增殖与迁移、轴突生长与导向、突触形成与修剪、神经环路的建立与可塑性、以及神经干细胞生物学。课程介绍发育异常导致的神经系统疾病，如神经管缺陷、自闭症谱系障碍等，结合经典实验和最新研究进展。
This course studies nervous system development from embryo to maturity. Topics include neural plate formation and neural tube closure, neural induction and patterning, neuronal proliferation and migration, axon growth and guidance, synapse formation and pruning, neural circuit establishment and plasticity, and neural stem cell biology. Covers developmental disorders like neural tube defects and autism spectrum disorders.
学生需查阅文献，整理参与斑马鱼神经管背腹轴模式建成的关键基因（如Shh、BMP、Wnt信号通路及下游转录因子），构建基因调控网络模型。使用系统生物学方法模拟基因表达的时空模式，分析关键基因突变对神经管发育的影响，撰写研究报告，培养学生的发育生物学建模能力。
Students review literature to identify key genes involved in zebrafish neural tube dorsoventral patterning (Shh, BMP, Wnt pathways and downstream transcription factors), and construct a gene regulatory network model. Using systems biology methods, they simulate spatiotemporal gene expression patterns and analyze effects of key gene mutations on neural tube development, developing developmental biology modeling skills.